The 40 Watt Club has been one of the launching pads for musical groups in the South. Some bands that played gigs early in their careers include:

The B-52's
Arlo Guthrie
Better Than Ezra
Black Crowes
Cake
Crash Test Dummies
Fishbone
Gregg Allman
Joan Osborne
The Killers
Matchbox 20
R.E.M.