The Mondrian hotel has long been popular with the rock crowd, attracting members of the Smashing Pumpkins, Guns and Roses, Public Enemy, Hole (with Courtney Love), The Who, Poison, the Cranberries, Gipsy Kings and others.

One of the lead "singers" for the pop duo Milli Vanilli tried to kill himself in 1991 here. Rob Pilatus took an overdose of pills, slashed his wrists, and tried to jump out of the ninth-floor window of this hotel before the police finally stopped him